Heart India

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 9  |  Issue : 2  |  Page : 108--113

Clinical, echocardiographic profile, and outcome of heart failure patients with preserved ejection fraction


MC John1, Jayaprasad Narayanapillai1, Suresh Madhavan1, VL Jayaprakash1, Raju George2 
1 Department of Cardiology, Government Medical College, Kottayam, Kerala, India
2 Department of Cardiology, Government Medical College, Ernakulam, Kerala, India

Correspondence Address:
Dr. Jayaprasad Narayanapillai
Department of Cardiology, Government Medical College, Kottayam, Kerala
India

Context: Approximately half of the patients with heart failure have preserved ejection fraction (HFpEF). Epidemiologic studies and randomized trials provide somewhat conflicting data regarding outcomes of HFpEF. Aims: The objective is to study the clinical and echocardiographic profile of patients admitted with HFpEF and estimate outcomes. Settings and Design: This is a prospective observational study on patients with new-onset HF requiring hospitalization and normal EF and evidence of diastolic dysfunction in echocardiography. Subjects and Methods: Risk factors for HFpEF, clinical features, and echocardiographic parameters were recorded. The primary outcome studied was mortality at 1 year and the secondary outcome was rehospitalization at 1 year. Statistical Analysis Used: Variables were analyzed using Student's t-test and Chi-square test. Univariate and multivariate analysis were done to find out predictors of outcomes. Results: A total of 104 patients admitted with the first episode of HF were found to have left ventricular ejection fraction ≥ 50% and diastolic dysfunction. Associated cardiac conditions were hypertension in 77.8%, diabetes in 38.5%, ischemic heart disease in 30.7%, and atrial fibrillation in 32.7%. In our study, 42 patients (40.1%) had rehospitalization within 1 year. The mortality rate at 1 year was 15.4% (16 patients). The parameters found to be significantly correlated with mortality in the univariate analysis included age, high BP, anemia, hyponatremia, low isovolumetric relaxation time, and higher E/e' ratio. Multivariate analysis showed advanced age, hyponatremia, and high E/e' to be independent predictors of mortality. Conclusions: Among hospitalized patients with new-onset HFpEF annual mortality rate is as high as 15.4%. Advanced age, hyponatremia, and high E/e' were found to be independent predictors of mortality.


How to cite this article:
John M C, Narayanapillai J, Madhavan S, Jayaprakash V L, George R. Clinical, echocardiographic profile, and outcome of heart failure patients with preserved ejection fraction.Heart India 2021;9:108-113


How to cite this URL:
John M C, Narayanapillai J, Madhavan S, Jayaprakash V L, George R. Clinical, echocardiographic profile, and outcome of heart failure patients with preserved ejection fraction. Heart India [serial online] 2021 [cited 2021 Dec 4 ];9:108-113
Available from: https://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=2;spage=108;epage=113;aulast=John;type=0